Background: Podoplanin is a mucin-type membrane protein mainly expressed on the endothelium of lymphatic vessels and variably expressed in tumor cells, such as squamous cell carcinomas, and in cancer associated fibroblasts (CAFs). High levels of podoplanin are associated with an increased incidence of metastasis to lymph nodes and decreased survival time of patients.

Validation: Each lot of conjugated antibody is quality control tested by staining tissue following the MIBI Staining Protocol optimized for the applicable tissue format with subsequent MIBIscope analysis using the appropriate positive and negative tissue field of views.

Recommended Usage: Human FFPE: 3 ug/mL dilution. For optimal results, the antibody should be titrated for each desired application.

MIBI technology: Learn more about MIBI™ Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.

References

Ugorski, M., Dziegiel, P., Suchanski, J. Podoplanin – a small glycoprotein with many faces. Am J Cancer Res. 2016; 6(2):370-86.

* Conjugate tested on human tissue.