HIF-1α [EP1215Y] Antibody – 160Gd

Catalog: 716004

Clone: EP1215Y

Isotype: Rabbit IgG

Reactivity: Human*

Application: MIBI-FFPE

Storage: Supplied in antibody stabilizer with 0.05% sodium azide. Store at 4°C

HIF-1a-IHC-staining-FFPE-human-clear-cell-RCC

IHC: HIF-1α staining of FFPE human clear cell RCC

HIF-1a-MIBI-staining-FFPE-human-clear-cell-RCC

MIBI: HIF-1α staining (cyan) of FFPE human clear cell RCC, costained with dsDNA (magenta)

HIF-1a-IHC-staining-FFPE-human-lung-adenocarcinoma

IHC: HIF-1α staining of FFPE human lung adenocarcinoma

HIF-1a-MIBI-staining-FFPE-human-lung-adenocarcinoma

MIBI: HIF-1α staining (cyan) of FFPE human lung adenocarcinoma, costained with dsDNA (magenta)

Background: Hypoxia-inducible factor 1 alpha (HIF1A) is a subunit of HIF1, a heterodimeric transcription factor that plays a critical role in the cellular response to hypoxia. HIF1-alpha regulates hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis.

Validation: Each lot of conjugated antibody is quality control tested by staining tissue following the MIBI Staining Protocol optimized for the applicable tissue format with subsequent MIBIscope analysis using the appropriate positive and negative tissue field of views. These results are pathologist verified.

Recommended Usage: Human FFPE: 1:100 dilution.
For optimal results, the antibody should be titrated for each desired application.

MIBI technology: Learn more about MIBI™ Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.

References
Frank R Sharp and Myriam Bernaudin, HIF1 and oxygen sensing in the brain. Nat Rev Neurosci. 2004 Jun;5(6):437-48.
P Carmeliet et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature, 1998 Jul 30;394(6692):485-90.

* Conjugate tested on human tissue.

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HIF-1α [EP1215Y] Antibody – 160Gd

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