Background: The mannose receptor CD206 is predominantly expressed on the surface of macrophages, dendritic cells and liver sinusoidal endothelial cells. CD206 mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation and, therefore, plays an important role in host defense. Expression of CD206 on tumor-associated macrophages has been associated with immunosuppression, tumorigenesis and resistance to cancer therapies.

Validation: Each lot of conjugated antibody is quality control tested by staining tissue following the MIBI Staining Protocol optimized for the applicable tissue format with subsequent MIBIscope analysis of stained tissue microarray using the appropriate positive and negative tissue field of views.

Recommended Usage: Human FFPE: 3.5 ug/mL dilution.
For optimal results, the antibody should be titrated for each desired application.

References
Pablo Scodeller et al. Precision targeting of tumor macrophages with a CD206 binding peptide. Sci Rep. 2017 Nov 7;7(1):14655.

* Conjugate tested on human tissue.