Background: CD11c is expressed by dendritic cells, monocytes, macrophages, neutrophils, and some B cells. CD11c is one of four β2 integrins along with CD11a, C11b and CD11d. CD11c is a receptor for fibrinogen and functions in chemotaxis and cell adhesion. Integrins mediate myeloid cell recruitment from the blood vessels into tissue and lymph nodes and contribute to the immunological synapse between T cells and antigen presenting cells.

Validation: Each lot of conjugated antibody is quality control tested by staining tissue following the MIBI Staining Protocol optimized for the applicable tissue format with subsequent MIBIscope analysis using the appropriate positive and negative tissue field of views.

Recommended Usage: Human FFPE: 1 ug/mL dilution. For optimal results, the antibody should be titrated for each desired application.

References

Schittenhelm, L., Hilkens, C.M., and Morrison, V.L. β2 Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function. Front Immunol. 2017; 20(8):1866.

* Conjugate tested on human tissue.